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大奖18pt18手机版:陈骐 教授

时间:2014-08-26浏览:11452

陈骐:

    博士生导师,福建省天然免疫生物学重点实验室主任,南方生物医学研究中心副主任,2012年度福建省高校领军人才资助人选。

    系所:南方生物医学研究中心

    Email:nfsw@fjnu.edu.cn

    通讯地址:福建福州闽侯区大奖18pt18手机版旗山校区理工楼11# 513室


  



 个人简介:
   陈骐,1985年毕业于大奖18pt18手机版生物系,获理学学士学位。19881992年分别获得中国农业科学院硕士与博士学位。1989年至1992年到美国Rutgers University做访问研究。1999年获美国Uinversity of Southern California分子药理和毒理学博士学位,后于Salk Institute做博士后及研究工作,原为洛克菲勒神经生物学研究所助理教授。2012年受聘于大奖18pt18手机版,并入选2012年度福建省高校领军人才。早年主要从事基因工程的研究工作,1994年后主要从事神经系统功能及相关疾病的研究,在世界上首次分离和克隆了一种新的小G蛋白鸟苷酸交换因子,并完成该基因剔除小鼠模型的构建。目前主要从事以下研究工作:

主要研究方向:

1、疾病的免疫调控机制研究。主要从事相关疾病的天然免疫调控机制的研究,包括癌症、感染与免疫性疾病、及神经退行性疾病新的分子信号通路、遗传及表观遗传学的致病机制、及其相关的功能与调控研究,为未来相关疾病的基因诊断及药物开发打下基础。

2、基因分子诊断及精准医学。通过高通量测序技术、单分子核酸与蛋白检测技术、生物信息学等新技术的应用,研究找寻相关疾病在血液等体液中的核酸、蛋白多肽等的特异分子标记物。并从引发疾病的基因突变、疾病易感的基因高风险位点、蛋白与核酸等生物标志分子表达的差异、以及表观遗传学调控的差别等方面着手,探讨这些因素间的内在联系,建立起相关疾病早期诊断的基因分子综合评估机制。

3、CRISPR/Cas9基因修饰技术的开发应用。CRISPR/Cas9基因修饰技术的开发应用。CRISPR/Cas9基因修饰技术是本世纪生物工程领域最重要的技术进展之一,将用该技术进行各种动物模型的制备,并探讨其在基因治疗中应用的可行性。

  4、抗体及免疫细胞治疗。免疫抗体与细胞治疗,是目前药物开发最前沿的领域,中心将紧随相关技术的进步,进行抗体治疗药物、CAR-T等细胞治疗技术的研究开发,并探讨其在癌症及免疫性疾病方面的应用基础。

5、动物胚胎工程及疫病防治。运用胚胎移植、动物克隆、CRISPR/Cas基因编辑等先进技术,研制开发动物的新型药物、疫苗以及工厂化生产动物优质胚胎等,为畜禽的遗传改良和健康养殖提供新技术、新产品、新品种(系),满足我国畜禽和特色经济动物养殖及防治的需求。

6、小分子化学药物的研究开发。通过使用生化及细胞模型,筛选、合成具免疫相关功能的化学小分子,研究其药物功能及药理机制,为进一步的临床应用开发打基础。

 

代表性文章:

 [1] Lai J, Luo X, Tian S, Zhang X, Huang S, Wang H, Li Q, Cai S and Chen Q*. Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation. Front. Pharmacol. 11:88. doi: 10.3389/fphar.2020.00088. Feb. 28, 2020..

[2] Linye Wu, Langjun Chen, Meng Kou, Yanqiu Dong, Weili Deng, Liang Ge, Hongli Bao, Qi Chen*, Daliang Li*. The ratiometric fluorescent probes for monitoring the reactive inorganic sulfur species (RISS) signal in the living cell. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. https://doi.org/10.1016/j.saa.2020.118141. Feb. 7, 2020.

[3] Yuanji Xu, Jiling Wang, Shaoli Cai, Guanghao Chen, Nanyang Xiao, Yajuan Fu, Qi Chen, Sufang Qiu. PNCK depletion inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells in vitro and in vivo. J Cancer 2019; 10(27):6925-6932. doi:10.7150/jca.33698.

[4] Su, Jingqian; Guo, Kai; Huang, Min; Liu, Yixuan; Zhang, Jie; Sun, Lijun; Li, Daliang; Pang, Ka-Lai; Wang, Guangce; Chen, Long; Chen, Youqiang*; Chen Qi*, and Huang, Luqiang*. Fucoxanthin, a Marine Xanthophyll Isolated From Conticribra weissflogii ND-8: Preventive Anti-Inflammatory Effect in a Mouse Model of Sepsis. August 2019, Frontiers in Pharmacology 10. DOI: 10.3389/fphar.2019.00906.

[5] Nanyang Xiao, Jingjing Wei, Shan Xu, Hekang Du, Miaohui Huang, Sitong Zhang, Lijun Sun*, Qi Chen*. cGAS Is Responsible for Spontaneous Lupus-Like Autoinmune Disorder Induced by TREX1 Mutation. J of Autoimmunity. https://doi.org/10.1016/j.jaut.2019.03.001.

[6] Qianping Luo, Koteswara Rao Bandib, Yanqiu Dong, Hongli Bao, Daliang Li*, Qi Chen*. Synthesis and living cell imaging of a novel fluorescent sensor for selective cupric detection.  Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. https://doi.org/10.1016/j.saa.2019.02.013. 2019.

[7] Bo Zhang, Weiwei Ye, Yangmiao Ye, Huan Zhou, Abdullah F. U. H. Saeed, Jing Chen, Jinying Lin, Vanja Per?ulija, Qi Chen, Chun-Jung Chen, Ming-Xian Chang, Muhammad Iqbal Choudhary & Songying Ouyang.Structural insights into Cas13b-guided CRISPR RNA maturation and recognition.  Cell Research 2018.

[8] Haitao Niu, Feng Li, Qingshui Wang, Zhoujie Ye, Qi Chen* and Yao Lin*. High expression level of MMP9 is associated with poor prognosis in patients with clear cell renal carcinoma.  Peer J 6:e5050. 2018.

[9] Qianping Luo, Yong Fan, Lili Lin, Jingjing Wei, Zuanfang Li, Yongkun Li, Susumu Nakae, Wei Lin and Qi Chen*. Interleukin-33 Protects Ischemic Brain Injury by Regulating Specific Microglial Activities. Neuroscience 385: 75-89, 2018.

[10] Yong Fan, Qianping Luo, Jingjing Wei,Ruhui Lin, Lili Lin, Yongkun Li, Zhaorong Chen, Wei Lin, Qi Chen*.Mechanism of Salvianolic Acid B Neuroprotection against Ischemia/Reperfusion Induced Cerebral Injury.Brain Research 2017, doi.org/10.1016/j.brainres.2017.11.027.

[11] Junzhong Lai, Hanze Wang, Qianping Luo, Shanlu Huang, Shujin Lin, Yansong Zheng, and Qi Chen*.The relationship between DNA methylation and Reprimo gene expression in gastric cancer cells.Oncotarget 2017,doi.org/10.18632/oncotarget.21296.

[12] Lixia Liu, Xiuqin Wu, Bingchen Zhang, Wei Yang, Yujiao Yin, Qi Chen*.Protective Effects of Tea Polyphenols on Exhaustive Exercise-Induced Fatigue, Inflammation and Tissue Damage.Food Nutr Res 2017, 61(1):1333390.  doi: 10.1080/16546628.2017.1333390.

[13] Hanze Wang, Huican Ke, Junzhong Lai, Yansong Zheng, Qianping Luo, Qi Chen*. A Modified Bisulfite Conversion Method for the Detection of DNA Methylation.Epigenetics 2017, 9 (7) :955-969.  doi:10.2217/epi-2016-0174.

[14] Hui Yang, Hanze Wang, Junyao Ren, Qi Chen,and Zhijian J. Chen.cGAS is Essential for Cellular Senescence.Proc Nat Acad Sci USA 2017, 114 (23) :E4612-E4620.doi:10.1073/pnas.1705499114.

[15] Jingqian Su, Huiying Liu, Kai Guo, Long Chen, Minhe Yang and Qi Chen*.Research Advances and Detection Methodologies for Microbe-Derived Acetylcholinesterase Inhibitors: A Systemic Review.Molecules 2017, 22(1). doi:10.3390/molecules22010176. 

[16] Qi Chen,Lijun Sun, Zhijian J Chen. Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing.Nature Immunology 2016,17(10): 1142-1149.

[17] Hanze Wang, Yansong Zheng, Junzhong Lai, Qianping Luo, Huican Ke, Qi Chen*.Methylation-Sensitive Melt Curve Analysis of the Reprimo Gene Methylation in Gastric Cancer.PLoS One DOI:10.1371/journal.pone.0168635 December 16, 2016.

[18] Qi ChenMarguerite Prior, Richard Dargusch, Amanda Roberts, Roland Riek, Ce? dric Eichmann, Chandramouli Chiruta, Tatsuhiro Akaishi, Kazuho Abe, Pamela Maher, David Schubert*. A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer's Disease.PLoS One 2011,6(12):1-17.

[19] Federico Herrera, Qi Chen, and David Schubert.Synergistic effect of retinoic Acid and cytokines on the regulation of glial fibrillary acidic protein expression.Journal of Biological Chemistry 2010,285(50):38915-38922

[20] Xianjin Zhou, Qi Chen,Katie Schaukowitch, John R Kelsoe, and Mark A Geyer.Insoluble DISC1-Boymaw Fusion Proteins Generated by the DISC1 Translocation. Molecular Psychiatry 2010, 15(7): 670–672

[21] Qi Chen, Charles A. Peto, G. Diane Shelton, Andrew Mizisin,Paul E. Sawchenko,and David Schubert.Loss of MOCA reveals a pathway leading to axonal degeneration.Journal of Neurosciences 2009,29(1):118 –130

[22] Joseph R. Burdo, Qi Chen, Nigel A. Calcutt, David Schubert?. The pathological interaction between diabetes and presymptomatic Alzheimer’s disease. Neurobiology of Aging 2009,1910–1917

[23] Federico Herrera, Qi Chen,Wolfgang H.Fischer, Pamela Maher, and David Schubert*.Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down’s syndrome.Cell Death and Differentiation 2009, 16(6): 910–920


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